Fc-engineered antibody expression vectors for human IgG4 hinge stabilization and structural engineering of bispecific antibodies. Includes S228P and S228P/L235E IgG4 variants, as well as dsFab-KiH and CrossMab-KiH expression systems.
ISOTYPE-STABILIZED & STRUCTURAL ENGINEERING ANTIBODY EXPRESSION VECTOR SELECTION GUIDE
Compare four expression-vector products to select an appropriate IgG4 stabilization backbone or bispecific antibody assembly platform.
| Catalog No. | Variant / System | Engineering Mechanism | Selection Guidance |
|---|---|---|---|
| AFV-09 | Human IgG4 (S228P) | S228P hinge stabilization | IgG4 backbone for studying reduced Fab-arm exchange. |
| AFV-33 | Human IgG4 (PE) | S228P / L235E | IgG4 hinge stabilization combined with Fc-effector attenuation. |
| AFV-34 | Human IgG1 (dsFab-KiH Pair Set) | Engineered Fab disulfide pairing + KiH Fc heterodimerization | Bispecific antibody assembly using engineered Fab disulfide pairing. |
| AFV-35 | Human IgG1 (CrossMab + KiH Set) | CH1–CL domain crossover + KiH Fc heterodimerization | Bispecific antibody assembly using CrossMab domain swapping. |
Product selection depends on antibody sequence, chain-pairing behavior, expression conditions, and intended functional properties. Confirm assembly, purity, and Fc-effector activity experimentally as appropriate.
Showing all 4 results
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Human IgG4 (S228P) — IgG4-Stabilized Core Hinge Isotype Vector
Price range: $680.00 through $1,240.00 -
Human IgG4 (PE) — IgG4-Stabilized & Effector-Silenced Isotype Vector
Price range: $680.00 through $1,240.00 -
Human IgG1 (dsFab-KiH Pair Set) — Disulfide-Engineered Bispecific Antibody Expression System
Price range: $2,158.00 through $2,998.00 -
Human IgG1 (CrossMab + KiH Set) — CH1-CL Domain Crossover & Knobs-into-Holes Bispecific Expression System
Price range: $2,158.00 through $2,998.00