Background
The activin type 2 receptors belong to a larger TGF-beta receptor family and modulate signals for transforming growth factor beta ligands. These receptors are involved in a host of physiological processes including, growth, cell differentiation, homeostasis, osteogenesis, apoptosis and many other functions. There are two activin type two receptors: ACVR2A and ACVR2B. Activin plays a significant role in reproduction. ACVR2 receptors are present in the testis during testicular development. ACR2A and ACVR2B was found to be localized primarily in the gonocytes as well as in sertoli cells.
The ACVR2 gene is often found inactivated in prostate cancer and tumors with microsatellite instability.
Product Details
| Source | NS0, Mouse myeloma cell line |
| Accession # | Q13705 |
| Sequence | Human Activin RIIB (Ser19 - Thr134) + Human IgG1 (Pro100-Lys330) + 6xHis tag (N-terminus to C-terminus) |
| Purification | Protein A/G purified and size-HPLC |
| Purity | >95%, by SDS-PAGE. |
| Activity | Measured by its ability to inhibit Activin A-induced hemoglobin expression in K562 human chronic myelogenous leukemia cells. |
| Endotoxin Level | <0.10 EU per 1 µg of the antibody by the LAL method |
| Formulation | 0.2 µm filtered solution in PBS |
| Reconstitution | Reconstitute at 0.5 mg/ml in sterile 1xPBS |
| Predicted Molecular Weight | 41 kDa |
| Shipping | The product is shipped with polar packs. Upon receipt, store it immediately at -20 to -70°C |
| Storage Conditions | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. • 12 months from the date of receipt at -20 to -70°C as supplied. • 1 month at 2 to 8°C under sterile conditions |
References
Attisano L, Wrana JL, Montalvo E, Massagué J. Activation of signalling by the activin receptor complex. Mol Cell Biol. 1996, 16(3):1066-1073.
Woodruff TK. Regulation of cellular and system function by activin. Biochem Pharmacol. 1998, 55(7):953-963.