DNA Aptamer against Protein A of Staphylococcus aureus
Background
Staphylococcal protein A (SpA) is a cell surface protein found in almost all strains of Staphylococcus aureus. It’s a key virulence factor that helps the bacteria evade the host’s immune response. SpA has many functions, including:
- Binding to immunoglobulins: SpA binds to the Fc portion of all human IgG subclasses except IgG3, which prevents antibodies and complement from attaching to the bacterial surface. This makes it harder for the body to clear the bacteria through phagocytosis.
- Causing inflammation: SpA is a major proinflammatory factor in the lungs, where it activates TNFR1, a surface receptor. This activates inflammatory responses in the airway epithelium.
- Altering the behavior of other bacteria: SpA can also affect other bacteria, such as Pseudomonas aeruginosa. For example, SpA can inhibit biofilm formation and phagocytosis by neutrophils.
Product Specification
Aptamer type: DNA aptamer
Aptamer length: 76 bp
Affinity KD: 84 ± 5 nM
Storage: keep at -20°C. DNA aptamers are guaranteed stable for 12 months when properly stored.