DNA Aptamer against Tumor Necrosis Factor Receptor Superfamily Member 9 (TNFRSF9) or 4-1BB
Background
TNF receptor superfamily member 9 (TNFRSF9), is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
Product Specification
Aptamer type: DNA aptamer
Aptamer length: 60 bp
Affinity KD: 2.32 nM
Storage: keep at -20°C. DNA aptamers are guaranteed stable for 12 months when properly stored.