Background
The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains – i.e. it is a heterodimer, and consists of two subunits, interleukin-7 receptor subunit alpha (IL-7R alpha; IL-7RA, CD127) and common-γ chain receptor (CD132). Interleukin-7 receptor is expressed on various cell types, including naive and memory T cells and many others. Interleukin-7 receptor has been shown to play a critical role in the development of lymphocytes.
Several diseases are associated with Interleukin-7 receptor including T-cell acute lymphoblastic leukemia, multiple sclerosis, rheumatoid arthritis and juvenile idiopathic arthritis.
Product Details
| Source | Human 293 cells (HEK293) |
| Accession # | P16871-1 |
| Sequence | Human IL-7R alpha (Glu 21 - Asp 239) + Human IgG1 (Pro100-Lys330) (N-terminus to C-terminus) |
| Purification | Protein A/G purified and size-HPLC |
| Purity | >95% as determined by SDS-PAGE. |
| Activity | Measured by its binding ability to human IL-7 protein (0.2 µg) with an EC50=0.032 µg/ml. |
| Endotoxin Level | <0.10 EU per 1 µg of the antibody by the LAL method |
| Formulation | 0.2 µm filtered solution in PBS |
| Reconstitution | Reconstitute at 0.5 mg/ml in sterile 1xPBS |
| Predicted Molecular Weight | 52 kDa |
| Shipping | The product is shipped with polar packs. Upon receipt, store it immediately at -20 to -70°C |
| Storage Conditions | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. • 12 months from the date of receipt at -20 to -70°C as supplied. • 1 month at 2 to 8°C under sterile conditions |
References
Mazzucchelli R, Durum SK. Interleukin-7 receptor expression: intelligent design. Nat Rev Immunol. 2007, 7(2):144-154.