Background
MCF-7 (Michigan Cancer Foundation-7) is a breast cancer cell line isolated in 1970 from a 69-year-old White woman and was established in 1973 by Herbert Soule and co-workers. The MCF-7 breast cancer cell line retained several characteristics of differentiated mammary epithelium, including the ability to process estradiol via cytoplasmic estrogen receptors and the capability of forming domes. Tumor necrosis factor alpha (TNF alpha) inhibits the growth of MCF-7 breast cancer cells. Treatment with anti-estrogens can modulate the secretion of insulin-like growth factor binding proteins. Omega-3 and 6 fatty acids, such as EPA, DHA, and AA, have been reported to inhibit MCF-7 cell line growth and proliferation. PIK3CA helical mutations were identified in MCF-7, but with low AKT activation.
Fusion BioLabs provides validated DNA aptamers against the MCF-7 breast cancer cell line.
Product Specification
Aptamer type: DNA aptamer
Aptamer length: 26 bp
Affinity KD: 30-50 nM by Cell-SELEX
Storage: keep at -20°C. DNA aptamers are guaranteed stable for 12 months when properly stored.