CEA/CD3 Bispecific Antibody

CEA/CD3 Bispecific Antibody

$289.00$889.00

CEA/CD3-bispecific T cell-engaging (BiTE) antibody

SKU: BSA-004 Category:

Background

Carcinoembryonic antigen (CEA) or carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) targeting BiTE is an artificial bispecific T-cell engager (BiTE). It enables a patient’s T cells to recognize malignant B cells. A molecule of CEA-targeting BiTE combines two binding sites: a CD3 is part of the T cell receptor and a CEA site for the target B cells as a tumor antigen.

CEA/CD3-bispecific T cell-engaging BiTE is composed of a humanized single-chain antibody recognizing CEA expressed by colorectal, pancreas, and other epithelial malignancies, and a de-immunized single-chain antibody specific for human CD3ε.

 

Product Details 

ReactivityHuman
SpecificityDetects human CEA and Human CD3ε in direct ELISA. This product is for research use only.
SourceCHO cell transient transfection
SequenceHuman CEA scFv+Human CD3ε scFv+6xHis tag (N-terminus to C-terminus)
PurificationAffinity purified from CHO cell culture supernatant
Purity>95% measured by SDS-PAGE.
Predicted MW54.1 kDa
ImmunogenHuman CEA and Human CD3ε
Endotoxin Level<0.10 EU per 1 µg of the antibody by the LAL method
Formulation0.2 µm filtered solution in PBS
ReconstitutionReconstitute at 0.5 mg/ml in sterile 1xPBS
ShippingThe product is shipped with polar packs. Upon receipt, store it immediately at -20 to -70°C
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
• 12 months from the date of receipt at -20 to -70°C as supplied.
• 1 month at 2 to 8°C under sterile conditions
Weight 0.5 lbs
Dimensions 1 × 1 × 1 in
size

50 µg, 200µg

Services

Recombinant Antibody ProductionHigh Quality Animal-free Antibody Production via Transient Transfection in CHO or HEK293 PlatformsLearn More
Antibody Fragments ProductionHigh Quality scFv, Fab, VHH Design & Production in Mammalian or Bacterial Expression SystemsLearn More
Biosimilar Antibody ProductionHigh Quality Animal-free Biosimilar Antibody Production via Transient Transfection in CHO Cell PlatformLearn More
Bispecific Antibody ProductionHigh Quality Animal-free Bispecific Antibody Production in Mammalian or Bacterial Expression SystemsLearn More
Antibody Isotype SwitchingSwitching Antibody to any Isotype and Any SpeciesLearn More