Recombinant Human Activin RIIA Protein with C-terminal human IgG1 Fc

Recombinant Human Activin RIIA Protein with C-terminal human IgG1 Fc

$368.00$1,449.00

Recombinant Human Activin RIIA Protein with C-terminal human IgG1 Fc

SKU: RPA-004 Category:

Background

The activin type 2 receptors belong to a larger TGF-beta receptor family and modulate signals for transforming growth factor beta ligands. These receptors are involved in a host of physiological processes including, growth, cell differentiation, homeostasis, osteogenesis, apoptosis and many other functions. There are two activin type two receptors: ACVR2A and ACVR2B. Activin plays a significant role in reproduction. ACVR2 receptors are present in the testis during testicular development. ACR2A and ACVR2B was found to be localized primarily in the gonocytes as well as in sertoli cells.

The ACVR2 gene is often found inactivated in prostate cancer and tumors with microsatellite instability.

 

Product Details

SourceNS0, Mouse myeloma cell line
Accession #P27037
SequenceHuman Activin RIIA (Met1 - Pro134) + Human IgG1 (Pro100-Lys330) (N-terminus to C-terminus)
PurificationProtein A/G purified and size-HPLC
Purity>95%, by SDS-PAGE.
ActivityMeasured by its ability to inhibit Activin A-induced hemoglobin expression in K562 human chronic myelogenous leukemia cells.
Endotoxin Level<0.10 EU per 1 µg of the antibody by the LAL method
Formulation0.2 µm filtered solution in PBS
ReconstitutionReconstitute at 0.5 mg/ml in sterile 1xPBS
Predicted Molecular Weight40 kDa
ShippingThe product is shipped with polar packs. Upon receipt, store it immediately at -20 to -70°C
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
• 12 months from the date of receipt at -20 to -70°C as supplied.
• 1 month at 2 to 8°C under sterile conditions

References

Schwall RH, Lai C. Erythroid differentiation bioassays for activin. Methods Enzymol. 1991, 198:340-346.

Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H. Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway. J Biol Chem. 2002, 277(21):19008-19018.

Weight 1 lbs
Dimensions 1 × 1 × 1 in
size

100 µg, 500 µg